Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

FFR and Quality of Life After PCI

Circulation; ePub 2018 Sep 18; Nishi, et al

Fractional flow reserve (FFR) and angina severity predicted quality of life (QOL) improvement after percutaneous coronary intervention (PCI) among patients with stable coronary artery disease (CAD), a recent study found. Researchers identified 706 stable patients with CAD from the FAME 1 and 2 trials who had at least 1 lesion with an FFR ≤0.80 which was treated with PCI and 185 patients with CAD who had no lesion with an FFR ≤0.80 and who were treated medically and served as a reference group. They found:

  • QOL improved significantly after PCI in each abnormal FFR tertile; it did not change in the reference group.
  • The lowest abnormal FFR subgroup had the greatest improvement in QOL at 1 month.
  • Lower FFR, greater delta FFR, and higher angina class were associated with the greatest magnitude of QOL improvement both at 1 month and 1 year, on mixed-effects models for repeated measures.


Nishi T, Piroth Z, De Bruyne B, et al. Fractional flow reserve and quality-of-life improvement after percutaneous coronary intervention in patients with stable coronary artery disease. [Published online ahead of print September 18, 2018]. Circulation. doi:10.1161/CIRCULATIONAHA.118.035263.

This Week's Must Reads

Trends in LDL-C and 2013 Treatment Guidelines, Clin Cardiol; ePub 2018 Nov 15; Superko, et al

PCSK9 Inhibitors Reduce Risk of CV Events, Nat Rev Cardiol; ePub 2018 Nov 12; Sabatine, et al

Risk Factors for CVD in Heterozygous FH, J Clin Lipidol; ePub 2018 Nov 7; Akioyamen, et al

Hypercholesterolemia Patients on Suboptimal Statins, J Atheroscler Thromb; ePub 2018 Oct 26; Kajinami, et al

Cholesterol Guidelines Stress Lifetime Approach, Circulation; ePub 2018 Nov 10; Grundy, et al

Must Reads in CAD & Atherosclerosis

CAD Severity as a Function of Patient Sex, Am Heart J; ePub 2018 Oct 2; Pagidipati, et al

Does Aspirin Prevent CV Events in Older Adults?, N Engl J Med; ePub 2018 Sep 16; McNeil, et al

FFR and Quality of Life After PCI, Circulation; ePub 2018 Sep 18; Nishi, et al

Does Dietary Diversity Promote a Healthy Weight?, Circulation; ePub 2018 Aug 9; de Oliveira, et al

Omega-3 Fatty Acids for Prevention of CVD, Cochrane Library; ePub 2018 Jul 18; Abdelhamid, et al