Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

5-year outcomes similar between PCI and CABG for left main CAD

Key clinical point: PCI may be considered an acceptable revascularization modality for selected patients with left main coronary artery disease.

Major finding: At 5 years, the primary composite of death, stroke, or MI occurred in 22.0% of patients in the PCI group and 19.2% of patients in the CABG group (P = .13).

Study details: EXCEL, a multicenter analysis of 1,905 patients with left main CAD and site-assessed low or intermediate CAD who were randomized to revascularization with PCI or with CABG, and followed for 5 years.

Disclosures: The EXCEL trial was funded by Abbott Vascular. Dr. Stone disclosed having relationships with numerous device and pharmaceutical companies but had no relevant disclosures for this study.


Stone G et al. TCT 2019. N Engl J Med. 2019 Sep 28. doi: 10.1056/NEJMoa1909406.