Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

DTC Genetic Tests Deliver High False-Positive Rates

Key clinical point: Only 19% of patients shared their direct-to-consumer (DTC) test results with their physician. Consider asking patients if they have undergone DTC genetic testing.

Major finding: High false-positive rates have been seen in recent studies that sought to confirm genotyping data from DTC genetic test results.

Expert Analysis: Andrew D. Coyle, MD, discussed a survey published in the Annals of Internal Medicine in 2016 on the percent of patients who share their DTC test results with their physicians and a 2018 study published in Genetics and Medicine on genetic test accuracy.

Disclosures: Dr. Coyle had no relevant disclosures to report.


Podium presentation at the 2019 annual meeting of the American College of Physicians.