Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Warfarin Boosts OA Risk in Rotterdam Study

Key clinical point: Warfarin therapy is independently associated with increased risk of OA.

Major finding: The risk of new-onset or progressive OA in individuals on warfarin was more than doubled, compared with nonusers.

Study details: The Rotterdam Study is a prospective, population-based cohort study of 15,000 participants, ongoing since 1990.

Disclosures: The presenter reported having no financial conflicts regarding the study, sponsored by Erasmus University and the Dutch government.


REPORTING FROM OARSI 2019 TORONTO – The use of warfarin or related vitamin K antagonists was associated with a more than 100% increased risk of incident or progressive knee or hip osteoarthritis in the Rotterdam Study, Cindy G. Boer reported at the OARSI 2019 World Congress.