Depressive symptoms are associated with an increased risk of incident atrial fibrillation (AF), a new study found. The analysis included 6,644 participants from the Multi-Ethnic Study of Atherosclerosis who were free of AF at baseline. The primary outcome was incident AF, identified by follow-up study visits ECGs, hospital discharge diagnoses, or Medicare claims data. Researchers found:
- 875 (13%) incident AF cases were detected over a median follow-up of nearly 13 years.
- A Center of Epidemiologic Studies Depression Scale score ≥16 and antidepressant use were associated with a 34% and 36% higher risk of AF, respectively.
- There were no significant associations observed for anger, anxiety, or chronic stress with development of AF.
Garg PK, O’Neal WT, Diez-Roux AV, Alonso A, Soliman EZ, Heckbert S. Negative affect and risk of atrial fibrillation: MESA. [Published online ahead of print December 19, 2018]. J Am Heart Assoc. doi:10.1161/JAHA.118.010603.