Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Dementia Progression in Men and Women with AF

Am J Cardiol; ePub 2018 Aug 3; Golive, et al

In both men and women who develop atrial fibrillation, dementia rates are increased and do not show sex-based differences in risk, a recent study found. Researchers examined patients who underwent coronary angiography and enrolled in a prospective cardiovascular database. Patients could not have a prior diagnosis of AF or dementia and had to have 5 years of follow-up for inclusion. Endpoints included incident AF and dementia. Among the details:

  • 35,608 patients were included in the study (40.4% female).
  • Women had lower rates of hypertension, diabetes, coronary artery disease (CAD), prior myocardial infarction (MI), but higher rates of stroke.
  • Men had a higher incidence of 5-year and long-term AF; however, women trended toward a higher incidence of 5-year and long-term dementia and stroke compared to men.
  • Women have higher rates of dementia over time than men, driven by higher baseline stroke rates and nontraditional cardiovascular risk factors.


Golive A, May HT, Bair TL, et al. Impact of gender on atrial fibrillation incidence and progression to dementia. [Published online ahead of print August 3, 2018]. Am J Cardiol. doi:10.1016/j.amjcard.2018.07.031.

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