Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Catheter Ablation for Ventricular Arrhythmias

Am J Cardiol; ePub 2018 Jul 18; Ogunbayo, et al

The presence of structural heart disease (SHD) during catheter ablation (CA) for ventricular arrhythmias (VA) increased the complication rate of major and any complications by approximately 3-fold for both and the hospital mortality by ≥20-fold compared to patients without SHD. This according to a recent study that compared trends, morbidity, and mortality associated with real-world practice of CA for VA based on the presence of SHD. Researchers collected and compared characteristics and outcomes of patients with and without SHD that underwent CA of VA. They found:

  • Among 34,907 patients that underwent CA for VA (1999-2013), 18,014 (51.6%) had SHD.
  • Major and all complications occurred among 1,135/18,014 (6.3%) and 2,139/18,014 (11.9%) patients with SHD, respectively, compared to 355/16,893 (2.1%) and 739/16,892 (4.4%) for patients without SHD.
  • More patients with SHD died vs those without SHD.
  • Heart failure was associated with an odds ratio of 3.09 for major complications for patients with SHD, while coronary artery disease OR for major complications was 2.47.
  • The 15-year study period was a significant increase in major complications in patients with SHD.


Ogunbayo GO, Charnigo R, Darrat Y, et al. Comparison of complications of catheter ablation for ventricular arrhythmias in adults with and without structural heart disease. [Published online ahead of print July 18, 2018]. Am J Cardiol. doi:10.1016/j.amjcard.2018.07.001.

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