Compared with anthracyclines, treatment with novel targeted chemotherapeutic agents (TCAs) was associated with a significantly reduced risk of new-onset arrhythmia diagnosis during the first 6 months of treatment, according to a recent study. 5,026 patients were identified, of whom 2,951 (58.7%) received TCAs and 2,075 (41.3%) received anthracycline chemotherapy. Cancer treatment-induced arrhythmia (CTIA) was defined as any new arrhythmia diagnosis code within 6 months after treatment initiation. Researchers found:
- In the overall cohort, 601 (12.0%) patients developed CTIA.
- Patients with CTIA were significantly older and more likely to have hypertension, diabetes mellitus, congestive heart failure, coronary disease, and sleep apnea.
- The incidence of CTIA at 6 months was significantly lower in the TCA group (9.3% vs 15.8%).
- In a multivariate analysis, treatment with TCAs compared with anthracycline chemotherapy was associated with a significantly lower risk of CTIA (HR, 0.60).
Nickel AC, Patel A, Saba NF, Leon AR, El-Chami MF, Merchant FM. Incidence of cancer treatment-induced arrhythmia associated with novel targeted chemotherapeutic agents. [Published online ahead of print October 13, 2018]. J Am Heart Assoc. doi:10.1161/JAHA.118.010101.
This Week's Must Reads
Clinician Beliefs on Statins & Patient Adherence, Am J Cardiol; ePub 2019 Jan 4; Lowenstern, et al
Adherence to Statin Therapy in US Adults, J Am Heart Assoc; ePub 2019 Jan 8; Colantonio, et al
Efficacy of Statins for Primary Prevention of CVD, Am Heart J; ePub 2019 Jan 10; Yebyo, et al
Prevalence of FH in Patients with Premature MI, Clin Cardiol; ePub 2019 Jan 13; Cui, Li, et al
Lp(a) Levels & CVD Risk in Patients with Diabetes, Atherosclerosis; ePub 2018 Dec 29; Saeed, et al
Must Reads in Arrhythmias & EP
Depressive Symptoms and Risk of Incident AF, J Am Heart Assoc; ePub 2018 Dec 19; Garg, et al
Anticoagulation in Patients with AF and HF, Clin Cardiol; ePub 2018 Dec 23; Contreras, et al
Catheter Ablation for AF in Adults with CHD, Heart Rhythm; ePub 2018 Dec 26; Liang, et al
Calcium & Vitamin D and Incidence of AF in Women, Am Heart J; ePub 2018 Dec 13; Boursiquot, et al
Early Postoperative VAs After CHD Surgery, Heart Rhythm; ePub 2018 Dec 4; Fuchs, et al