Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Calcium & Vitamin D and Incidence of AF in Women

Am Heart J; ePub 2018 Dec 13; Boursiquot, et al

In a large cohort of postmenopausal women, calcium and vitamin D (CaD) supplementation had no effect on incidence of atrial fibrillation (AF), a recent study found. Researchers performed a secondary analysis of the Women’s Health Initiative (WHI) trial on CaD supplementation vs placebo to determine its efficacy for AF prevention. They found:

  • Among 16,801 WHI participants, there were 1,453 (8.6%) cases of incident AF over an average of 4.5 years, at an average rate of 19.9 events per 1,000 person-years.
  • There was no significant difference in incident AF rates between the CaD and placebo arms.
  • After multivariate adjustment, there was no significant association between baseline 25-hydroxyvitamin D serum levels and incident AF.


Boursiquot BC, Larson JC, Shalash OA, et al. Vitamin D with calcium supplementation and risk of atrial fibrillation in postmenopausal women. [Published online ahead of print December 13, 2018]. Am Heart J. doi:10.1016/j.ahj.2018.12.006.

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