Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Serum Uric Acid, Silent MI & Mortality

Am J Cardiol; ePub 2018 Dec 19; Ahmad, et al

There is a strong association of uric acid (UA) with silent myocardial infarction (SMI) or morality in the general population, a recent study found. The analysis included 6,323 participants (mean age 58.4 years, 54% women, and 49.7% non-Hispanic whites) without clinical cardiovascular disease (CVD) from NHANES-III. Researchers found:

  • The higher baseline level of UA was associated with higher odds of baseline SMI.
  • During a median follow-up of 14 years, there were 1,916 all-cause deaths of which 774 were CVD deaths.
  • Compared to those in the lowest UA quartile values and without SMI, those with the highest UA had a 29% increased risk of all-cause mortality; this risk increased by 107% in the presence of SMI.
  • Similar results were observed for CVD mortality.
  • SMI carries an increased risk of all-cause and CVD mortality only in higher quartiles of UA.

Citation:

Ahmad MI, Dutta A, Anees MA, Soliman EZ. Interrelations between serum uric acid, silent myocardial infarction and mortality in the general population. [Published online ahead of print December 19, 2018]. Am J Cardiol. doi:10.1016/j.amjcard.2018.12.016.

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