Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Novel cardiac troponin protocol rapidly rules out MI

Key clinical point: A novel early rule-out pathway for MI based on a single high-sensitivity cardiac troponin I test proved effective and safe in a major randomized trial.

Major finding: The early rule-out pathway reduced length of stay by 3.3 hours.

Study details: HiSTORIC was a 2-year, prospective, stepped-wedge, cluster-randomized, controlled trial in 31,492 consecutive patients with suspected acute coronary syndrome who presented to seven participating Scottish hospitals.

Disclosures: The study was funded by the British Heart Foundation. The presenter reported receiving research grants from Abbott Diagnostics and Siemens.


Mills NL. ESC 2019, Abstract 2309.