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Hypertensive Disorders of Pregnancy in SLE Contribute to Later CV Outcomes

Key clinical point: Women with systemic lupus erythematosus and hypertensive disorders of pregnancy are at increased risk of incident hypertension and cardiovascular outcomes after pregnancy at young ages and should be monitored and considered for treatment.

Major finding: A history of hypertensive disorders of pregnancy in women with systemic lupus erythematosus was associated with about a twofold higher rate of cardiovascular outcomes regardless of multiple sensitivity analyses both before and after adjusting for maternal age at delivery, county of birth, education, body mass index, and first-trimester smoking.

Study details: A population-based, longitudinal cohort of 3,340 women in the Swedish Medical Birth Register, including 450 with prevalent systemic lupus erythematosus.

Disclosures: Several authors reported research grants from the National Institutes of Health, the Karolinska Institute, the Swedish Research Council, Swedish Heart-Lung Foundation, Stockholm County Council, the King Gustaf V 80th Birthday Fund, the Swedish Rheumatism Association, and Ingegerd Johansson’s Foundation that helped to fund the study. All authors reported having no competing interests.


Simard JF et al. Arthritis Care Res. 2020 Jan 31. doi: 10.1002/acr.24160.