Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Heart disease risk rises with gut metabolite linked to red meat

Key clinical point: Increases in trimethylamine N-oxide were significantly linked with greater heart disease risk over 10 years.

Major finding: Women in the top tertile of trimethylamine N-oxide had a significantly increased risk of coronary heart disease (relative risk, 1.58), compared with other tertiles.

Study details: The data come from a prospective, nested, case-control study of coronary heart disease incidence in 760 women who were healthy at baseline and participants in the Nurses’ Health Study.

Disclosures: The study was sponsored in part by the National Institutes of Health, the Boston Obesity Nutrition Research Center, and the United States–Israel Binational Science Foundation. The researchers had no financial conflicts to disclose.


Heianza Y et al. J Am Coll Cardiol. 2020 Feb 17. doi: 0.1016/j.jacc.2019.11.060.