Clinical Edge

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Colorectal cancer risk elevated in anticoagulated AF patients with lower GI bleeding

Key clinical point: Patients with atrial fibrillation who are treated with oral anticoagulants and then suffer from lower GI bleeding have a higher risk of colorectal cancer.

Major finding: ll age groups had a higher risk of colorectal cancer after lower GI bleeding, compared with patients without bleeding, especially patients aged 65 or younger (risk ratio, 24.2 95% confidence interval, 14.5-40.4).

Study details: A nationwide retrospective study of 125,418 Danish patients with AF.

Disclosures: Two of the authors are employees at Bristol-Myers Squibb and Pfizer, respectively. Six additional authors reported receiving grants, speaker honoraria and consulting fees from various pharmaceutical companies. The remaining authors reported no conflicts of interest.


Rasmussen PV et al. Eur Heart J. 2020 Feb 7. doi: 10.1093/eurheartj/ehz964.