Among patients with type 2 diabetes (T2D) and recent acute coronary syndromes (ACS), average blood pressure (BP) <130/80 mm Hg were associated with worsened cardiovascular (CV) outcomes over the average follow-up period in the EXAMINE trial. The study included 5,380 patients with T2D and recent ACS. Risks of major adverse cardiac events and CV death or heart failure (HF) were analyzed. Researchers found:
- A U-shaped relationship between CV outcomes and BPs was observed.
- Adjusted hazard ratios (HRs) for both major adverse cardiac events and CV death or HF were significantly higher in patients with systolic BPs <130 mm Hg.
- HRs for major adverse cardiac events and for CV death or HF were significantly higher for diastolic BPs <80 mm Hg.
White WB, Jalil F, Cushman WC, et al. Average clinician measured blood pressures and cardiovascular outcomes in patients with type 2 diabetes mellitus and ischemic heart disease in the EXAMINE trial. [Published online ahead of print October 14, 2018]. J Am Heart Assoc. doi:10.1161/JAHA.118.009114.
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