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Visceral, Subcutaneous Fat and Bone Strength Link

J Bone Miner Res; ePub 2017 Oct 30; Glass, et al

There is a negative relationship between peripheral bone strength and visceral adipose tissue (VAT) in girls, but greater total and central adiposity in boys, suggesting that these factors play a role in adequate acquisition of bone strength during adolescence, a recent study found. This study evaluated the longitudinal relationships among VAT, subcutaneous adipose tissue (SAT), and peripheral bone strength during adolescence. Sex-specific analyses evaluated the longitudinal bone-fat relationship from ages 11–19 years with linear mixed models using biological age as the time variable and adjusted for limb length and lean mass in 182 girls and 167 boys. They found:

  • Fat mass and SAT were positively associated with strength-strain index (SSI) (radius: 0.07±0.02, 0.05±0.02, 0.041, respectively; tibia: 0.09±0.02, 0.08±0.02, respectively) prior to, but not following adjustment for lean mass in girls.
  • In contrast, fat mass and SAT were negatively associated with radial SSI, both before and after adjustment for lean mass in boys (fat mass: −0.05±0.01; SAT: −0.04±0.01).
  •  In full models, negative associations were limited to VAT in girls and included radial (−0.06±0.02) and tibial SSI (−0.04±0.02).
Citation:

Glass NA, Torner JC, Letuchy EM, et al. Do visceral or subcutaneous fat influence peripheral cortical bone strength during adolescence? A longitudinal study. [Published online ahead of print October 30, 2017]. J Bone Miner Res. doi:10.1002/jbmr.3325.

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