Distinct clinical features are present in systemic sclerosis (SSc) patients who are at risk of developing severe gastrointestinal (GI) dysmotility, according to a recent study. This finding is not only important clinically but also suggests that a unique pathological process is present in these patients. Patients with SSc who required supplemental nutrition (enteral or parental tube feeding) were compared to SSc patients with mild GI symptoms in a cross-sectional analysis. The association between severe GI dysmotility and clinical and serological features was examined using logistic regression. Researchers found:
- SSc patients with severe GI dysmotility (n=66) were more likely than those patients with mild GI symptoms (n=1,736) to be male, have myopathy, and sicca symptoms, even after adjusting for potential confounders.
- Baseline features that associate with the future development of severe GI dysfunction included male sex and myopathy.
McMahan Z, Paik JJ, Wigley FM, Hummers LK. Determining the risk factors and clinical features associated with severe gastrointestinal dysmotility in systemic sclerosis. [Published online ahead of print November 28, 2017]. Arthritis Care Res. doi:10.1002/acr.23479.
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