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46-Year Trends in SLE Mortality in the US

Ann Intern Med; ePub 2017 Oct 31; Yen, et al

Rates of systemic lupus erythematosus (SLE) mortality in the US have decreased since 1968 but remain high relative to non-SLE mortality, and significant sex, racial, and regional disparities persist, according to a recent study. Researchers conducted a population-based study using a national mortality database and census data (there were 50,249 SLE deaths and 100,851,288 non-SLE deaths from 1968 through 2013). They found:

  • During this period, the SLE age-standardized mortality rates (ASMR) decreased less than the non-SLE ASMR, with a 34.6% cumulative increase in the ratio of the former to the latter.
  • The non-SLE ASMR decreased every year starting in 1968, whereas the SLE ASMR decreased between 1968 and 1975, increased between 1975 and 1999, and decreased thereafter.
  • Similar patterns were seen in both sexes, among black persons, and in the South.
  • Females, black persons, and residents of the South had higher SLE ASMRs and larger cumulative increases in the ratio of the SLE to the non-SLE ASMR (31.4%, 62.5%, and 58.6%, respectively) than males, other racial/ethnic groups, and residents of other regions, respectively.
Citation:

Yen EY, Shaheen M, Woo JMP, et al. 46-year trends in systemic lupus erythematosus mortality in the United States, 1968 to 2013: A nationwide population-based study. [Published online ahead of print October 31, 2017]. Ann Intern Med. doi:10.7326/M17-0102.

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