Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Cochrane on Corticosteroids for Nausea, Vomiting

Cochrane; 2017 Jul 3; Vayne-Bossert, et al

There is not enough quality evidence to support or refute the efficacy of corticosteroids on nausea and vomiting not related to chemotherapy, radiotherapy, or surgery in adults with cancer, according to a Cochrane review of 3 studies involving 451 individuals.

2 studies compared dexamethasone to placebo. The third looked at other medicines in various combinations, including metoclopramide, chlorpromazine, tropisetron, and dexamethasone. Among the findings:

  • There was very low-quality evidence of the effects of steroids on nausea and vomiting in cancer patients.
  • There was no evidence about how steroids work in different types of cancer.
  • There were few reported side effects, and the drugs were generally well tolerated.

Vayne-Bossert P, Haywood A, Good P, Khan S, Rickett K, Hardy J. Corticosteroids for adult patients with advanced cancer who have nausea and vomiting (not related to chemotherapy, radiotherapy, or surgery). Cochrane Database of Systematic Reviews 2017, Issue 7. Art. No.: CD012002. doi:10.1002/14651858.CD012002.pub2.

This Week's Must Reads

Abemaciclib as Initial Therapy for Advanced BC, J Clin Oncol; 2017 Nov 10; Goetz, Toi, et al

BC Recurrence Risk Post-Endocrine Therapy Assessed, N Engl J Med; 2017 Nov 9; Pan, Gray, et al

The Value of an Embedded Palliative Care Program, Breast Cancer Res Treat; ePub 2017 Oct 30; Rabow, et al

Does Weight Gain Impact BC Disease Recurrence?, Clin Breast Cancer; ePub 2017 Nov 8; Raghavendra, et al

Abemaciclib + Fulvestrant in Advanced BC Evaluated, J Clin Oncol; 2017 Sep 1; Sledge, Toi, et al

Must Reads in Preventive Care

Cochrane on Corticosteroids for Nausea, Vomiting, Cochrane; 2017 Jul 3; Vayne-Bossert, et al

Cochrane Evaluates Efficacy of Cancer Pain Meds, Cochrane; 2017 Jul 6; Wiffen, et al/Jul 12; Derry, et al/Jul 12; Wiffen, et al

Do Genomic Testing Cancer Risk Results Alter Behavior?, J Clin Oncol; ePub 2016 Dec 12; Gray, et al