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Predicting 21-Gene Recurrence Score Test Uptake

Clin Breast Cancer; 2017 Nov 29; Hull, et al

Uptake of the 21-gene recurrence score test in patients with node negative, hormone-receptor positive, HER2 negative breast cancer appeared to be influenced by site of care and tumor type, according to a retrospective cohort study involving 328 individuals. Investigators looked at patient and site of care characteristics, and whether these impacted receipt of the 21-gene test in newly-diagnosed participants. Among the results:

  • One-fourth of patients had the 21-gene test.
  • 3 in every 10 sought care at a VA center where no tests were ordered.
  • Patients who received care at a VA center with women’s health services were 84% more likely to receive the test.
  • Those with tumor characteristics meeting the NCCN 2010 test criteria were >3 times more likely to receive the test.
  • Increasing age and fee-based care negatively predicted test uptake.
  • Most tested patients received guideline-based care.

Citation:

Hull L, Lynch J, Berse B, et al. Clinical impact of the 21-gene recurrence score test within the Veterans Health Administration: Utilization and receipt of guideline-concordant care. [Published online ahead of print November 29, 2017]. Clin Breast Cancer. doi:10.1016/j.clbc.2017.11.018.

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