Among infertile women, preconceptional thyroid-stimulating hormone (TSH) ≥2.5 mIU/L is not associated with adverse reproductive outcomes; however, antithyroid peroxidase (TPO) antibodies are associated with increased risk of miscarriage and decreased probability of live birth. This according to a secondary analysis of data from 2 multicenter, randomized, controlled trials with multivariable logistic regression analyses performed to assess the association between preconceptional TSH levels and anti-TPO antibodies. Serum samples from 1,468 infertile women were utilized with cumulative conception, clinical pregnancy, miscarriage, and live birth rates calculated. Researchers found:
- Conception, clinical pregnancy, miscarriage, and live birth rates did not differ between patients with TSH ≥2.5 mIU/L vs TSH <2.5 mIU/L.
- Women with anti-TPO antibodies had similar conception rates but higher miscarriage rates and lower live birth rates vs those without anti-TPO antibodies.
- There were elevated odds of miscarriage (OR, 2.17) and lower odds of live birth (OR, 0.58) in patients with anti-TPO antibodies.
Seungdamrong A, Steiner AZ, Gracia CR, et al. Preconceptional antithyroid peroxidase antibodies, but not thyroid-stimulating hormone, are associated with decreased live birth rates in infertile women. [Published online ahead of print October 25, 2017]. Fertil Steril. doi:10.1016/j.fertnstert.2017.08.026.
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