A recent study confirmed established and identified novel predictors of Parkinson disease (PD) motor progression. Researchers used genetic data and baseline molecular and clinical variables from patients with PD and healthy controls to construct an ensemble of models to predict the annual rate of change in combined scores from the Movement Disorder Society—Unified Parkinson's Disease Rating Scale (MDS-UPDRS) parts II and III. 117 healthy controls and 312 patients with PD from the Parkinson’s Progression Markers Initiative (PPMI) study were available for analysis, and 317 patients with PD from the Longitudinal and Biomarker Study in Parkinson’s disease (LABS-PD) were available for validation. They found:
- A strong performance was observed within the PPMI cohort and significant—albeit reduced—performance in the LABS-PD cohort.
- Individual predictive features identified from PPMI data were confirmed in the LABS-PD cohort.
- These included significant replication of higher baseline MDS-UPDRS motor score, male sex, and increased age, as well as a novel PD-specific epistatic interaction, all indicative of faster motor progression.
Latourelle JC, Beste MT, Hadzi YC, et al. Large-scale identification of clinical and genetic predictors of motor progression in patients with newly diagnosed Parkinson's disease: A longitudinal cohort study and validation. [Published online ahead of print September 25, 2017]. Lancet Neurol. doi:10.1016/S1474-4422(17)30328-9.
This Week's Must Reads
Evaluating Near-Fallers and Fallers with MS, Mult Scler Relat Disord; ePub 2017 Nov 21; Fritz, et al
Physical, Cognitive Functions in Elderly with MS, J Geriatr Phys Ther; ePub 2017 Dec 1; Bollaert, Motl
Healthy Diet, Lifestyle Linked with Less Disability, Neurology; ePub 2017 Dec 6; Fitzgerald, et al
Black Hole Assessment Method in Multiple Sclerosis, Mult Scler Relat Disord; ePub 2017 Dec 2; Adusumilli, et al
Age Is Essential Modifier of Drug Efficacy in MS , Front Neuro; ePub 2017 Nov 10; Weideman, et al
Must Reads in Parkinson's Disease
Sleep Fragmentation Linked with PD in Older Adults, Mov Disord; ePub 2017 Oct 30; Sohail, Yu, et al
Decline of Driving Safety in Persons with PD, Neurology; ePub 2017 Oct 11; Uc, Rizzo, et al
Detection of Predictors of PD Motor Progression, Lancet Neurol; ePub 2017 Sep 25; Latourelle, et al
Plasma HC Linked with Cognitive Function in PD, Parkinson Relat Disord; ePub 2017 Aug 9; Licking, et al
Motor Subtype Changes in Early Parkinson's Disease, Parkinsonism Relat Disord; ePub 2017 Jul 21; Eisinger, et al