Changes in the immune system occur during amyotrophic lateral sclerosis (ALS) and may contribute to the pathologic features of ALS, a recent study found. In this longitudinal cohort study, leukocytes were isolated from peripheral blood samples from both controls and participants with ALS at the ALS Clinic of the University of Michigan, from June 18, 2014, through May 26, 2016. Follow-up visits occurred every 6 to 12 months. 35 controls (17 women [48.6%] and 18 men [51.4%]; mean [SD] age, 63.5 [9.9] years) and 119 participants with ALS (50 women [42.0%] and 69 men [68.0%]; mean [SD] age, 61.4 [11.5] years) were enrolled; 51 participants with ALS provided samples at multiple points. Researchers found:
- Compared with controls, participants with ALS had increased mean counts (× 106/mL) of total leukocytes (4.57 vs 5.53), neutrophils (2.87 vs 3.80), CD16+ monocytes (0.03 vs 0.04), CD16− monocytes (0.25 vs 0.29), and natural killer cells (0.13 vs 0.18).
- There was also an acute, transient increase in a population of CD11b+ myeloid cells expressing HLA-DR, CD11c, and CX3CR1.
Murdock BJ, Zhou T, Kaslan SR, Little RJ, Goutman SA, Feldman EL. Correlation of peripheral immunity with rapid amyotrophic lateral sclerosis progression. [Published online ahead of print September 25, 2017]. JAMA Neurol. doi:10.1001/jamaneurol.2017.2255.
This Week's Must Reads
Possible Link: Hepatic Steatosis and Brain Aging, JAMA Neurol; ePub 2017 Nov 20; Weinstein, et al
Neurologic Drug Shortages May Compromise Care, Neurology; ePub 2017 Nov 15; Omorodion, et al
Sleep Fragmentation Linked with PD in Older Adults, Mov Disord; ePub 2017 Oct 30; Sohail, Yu, et al
Dietary Sodium to Potassium Ratio and Stroke Risk, Stroke; ePub 2017 Oct 10; Willey, Gardener, et al
Sleep Apnea Did Not Accelerate Kidney Decline, Sleep; ePub 2017 Nov 3; Canales, Hagen, et al
Must Reads in Neuromuscular Disorders
FDA Approves Soliris for Generalized MG, Alexion news release; 2017 Oct 23
Immune Changes in ALS Bear Closer Observation, JAMA Neurol; ePub 2017 Sep 25; Murdock, et al
FDA Approves Drug to Treat Duchenne MD, FDA news release; 2017 Feb 9
Trigeminal Neuralgia Often Precedes MS Diagnosis, Int J MS Care; ePub 2017 Jan 31; Fallata, et al
Agent in Well Water, Motor Neuron Disease Linked, Amyotroph Lateral Scler Frontotemporal Degener; ePub 2016 Dec 25; Schwartz, et al