The risk of migraine is increased in obese and underweight individuals, according to a recent meta-analysis conducted by 2 independent reviewers. A total of 12 studies, encompassing data from 288,981 unique participants, were included. They found:
- The age- and sex-adjusted pooled risk of migraine in those with obesity was increased by 27% compared with those of normal weight and remained increased after multivariate adjustments.
- Although the age- and sex-adjusted pooled migraine risk was increased in overweight individuals, significance was lost after multivariate adjustments.
- The age- and sex-adjusted pooled risk of migraine in underweight individuals was marginally increased by 13% compared with those of normal weight and remained increased after multivariate adjustments.
Gelaye B, Sacco S, Brown WJ, Nitchie HL, Ornello R, Peterlin L. Body composition status and the risk of migraine. A meta-analysis. [Published online ahead of print April 12, 2017]. Neurology. doi:10.1212/WNL.0000000000003919.
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