Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Cochrane on Detecting CRC in Patients with IBD

Cochrane; 2017 Sep 18; Bye, Nguyen, Parker, et al

Colonoscopic surveillance in patients with inflammatory bowel disease (IBD) may lower the risk of developing colorectal cancer (CRC) and death associated with it, according to a Cochrane review of 5 trials involving nearly 7,200 individuals. Among the findings, based on very low-quality evidence:

  • The surveillance group had lower cancer rates; odds were reduced by 42%.
  • The surveillance group had lower rates of CRC-related death; odds were reduced by 64%.
  • The surveillance group had more early state disease detected.
Citation:

Bye W, Nguyen T, Parker C, Jairath V, East J. Strategies for detecting colon cancer in patients with inflammatory bowel disease. Cochrane Database of Syst Rev. 2017, Issue 9. Art. No.: CD000279. doi:10.1002/14651858.CD000279.pub4.

This Week's Must Reads

Cochrane on Bisphosphonates for Breast Cancer, Cochrane; 2017 Oct 30; O'Carrigan, Wong, et al

Fiber Intake and Survival After CRC Diagnosis, JAMA Oncol; ePub 2017 Nov 2; Song, Wu, et al

Selecting Patients with Advanced NSCLC for Chemo, JAMA Oncol; ePub 2017 Nov 1; Shen, Chang, et al

Predicting CV Risk in Childhood Cancer Survivors, J Clin Oncol; ePub 2017 Nov 2; Chow, Chen, et al

CD8+ Tumor-Infiltrating Lymphocytes and Ovarian Ca, JAMA Oncol; ePub 2017 Oct 12; OTTA Consortium

Must Reads in Gastroenterology

Fiber Intake and Survival After CRC Diagnosis, JAMA Oncol; ePub 2017 Nov 2; Song, Wu, et al

Cochrane on Detecting CRC in Patients with IBD, Cochrane; 2017 Sep 18; Bye, Nguyen, Parker, et al

FDA Approves Keytruda for Advanced Gastric Ca, Merck news release; 2017 Sep 22

FDA Approves Opdivo for Hepatocellular Carcinoma, Bristol-Myers Squibb news release; 2017 Sep 22

Cochrane on Heparin Impact in People with Cancer , Cochrane; 2017 Sep 11; Akl, Kahale, et al