Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Severe Respiratory Illness Linked to Rhinovirus

Clin Infect Dis; ePub 2017 Nov 23; Prill, et al

Rhinoviruses were commonly associated with severe respiratory illness, alongside EV-D68, during a nationwide outbreak in the United States in 2014, with clinical characteristics largely similar among those with EV-D68, RV-A, RB-B, or RV-C. Respiratory specimens from pediatric and adult patients with respiratory illness were submitted to CDC during August-November 2014. Initial laboratory testing focused on identification of EV-D68, while the negative specimens were typed by molecular sequencing to identify additional enterovirus (EV) and rhinovirus (RV) types. Researchers found:

  • Among 2,629 typed specimens, 1,012 were EV-D68 and 81 (3.1%) represented other EV types; 968 were RVs (37%) covering 114 types and grouped into 3 human RV species; and 568 (22%) had no RV or EV detected.
  • EV-D68 was more frequently identified in patients presenting earlier in the study period.
  • Clinical syndromes and ICU admissions by age were largely similar among those with EV-D68 and RV species.

Citation:

Prill MM, Dahl R, Midgley CM, et al. Severe respiratory illness associated with rhinovirus during the EV-D68 outbreak in the United States, August–November 2014. [Published online ahead of print November 23, 2017]. Clin Infect Dis. doi:10.1093/cid/cix1034.

This Week's Must Reads

Seasonal Incidence of Symptomatic Influenza in US, Clin Infect Dis; ePub 2017 Dec 1; Tokars, et al

Sustaining Reduction Rates for Hospital-Onset CDI, Am J Infect Control; ePub 2017 Nov 21; Khoury, et al

Prevalence of Anal HPV Infection in Men with HIV, J Infect Dis; ePub 2017 Dec 4; Patel, Bush, et al

Inflammation, Coagulation & Risk in ART Initiation, Open Forum Infect Dis; ePub 2017 Nov 28; Baker, et al

FDA Approves Isentress for Tx of HIV in Newborns, Merck news release; 2017 Nov 29

Must Reads in Emerging Infections

Severe Respiratory Illness Linked to Rhinovirus, Clin Infect Dis; ePub 2017 Nov 23; Prill, et al

Seroreactivity to C6 Peptide in B. Miyamotoi Infections, Clin Infect Dis; ePub 2017 Nov 15; Molloy, et al

Regional Strategies to Limit Spread of CRE , Am J Infect Control; 2017 Nov 1; Gohil, et al

TB Diagnosis Among Foreign-Born Persons in the US, MMWR; ePub 2017 Mar 24; Tsang, Langer, et al

CT Scan Before Lumbar Puncture in Adults with CAM, Clin Infect Dis; ePub 2017 Mar 21; Salazar, et al