Adding cytogenetics, thrombocytopenia, and red cell transfusion dependence as risk factors appears to improve the Dynamic International Prognostic Scoring System (DIPSS), according to a study involving 233 individuals with myelofibrosis (MF). Investigators sought to determine if the enhanced system would predict post- hematopoietic cell transplantation (HCT) outcomes better than DIPSS-alone. Among the results:
- 5-year overall survival rate for patients with low/int-1 risk MF was 78%.
- Relapse and treatment-related mortality rates were 5% and 20%, respectively.
- 5-year overall survival rate in patients with high-risk MF was 35%.
- Relapse and treatment-related mortality rates were 28% and 40%, respectively.
- HCT-comorbidity index of ≥3 was linked with higher non-relapse and overall mortality, and lower relapse-free survival.
- Older patients were 3 times more likely to experience relapse.
- At a median follow-up of 8 years, ~half of patients had survived.
The authors noted that the findings may help improve the ability to advise patients about transplant timing.
Bannow B, Salit R, Storer B, et al. Hematopoietic cell transplantation for myelofibrosis: DIPSS plus risk predicts post-transplant outcomes. [Published online ahead of print September 29, 2017]. Biol Blood Marrow Transplant. doi:10.1016/j.bbmt.2017.09.016.
This Week's Must Reads
Guideline on Platelet Transfusion in Ca Patients, J Clin Oncol; ePub 2017 Nov 28; Schiffer, et al
Encourage This Behavior in Childhood ALL Survivors, Cancer; ePub 2017 Dec 4; Howell, Wilson, et al
Adipokines, Swelling, & Adiposity in HCT Survivors, Biol Blood Marrow Transplant; ePub 2017 Nov 29; Ketterl, et al
Prognostic Testing Patterns, CLL Outcomes Assessed, Clin Lymphoma Myeloma Leuk; ePub 2017 Dec 5; Mato, et al
Outcomes Post-AlloSCT in DHL/DEL Lymphomas, Biol Blood Marrow Transplant; ePub 2017 Nov 28; Herrera, et al
Must Reads in Myelodysplastic Syndrome
Myeloma Precursor More Prevalent in Some Blacks, Blood Cancer J; ePub 2017 Oct 20; Landgren, et al
This Improves Survival After HLA-Haplo Transplant, Biol Blood Marrow Transplant; ePub 2017 Oct 18; McCurdy, et al
Adding This to DIPSS Helps HCT Outcome Prediction, Biol Blood Marrow Transplant; ePub 2017 Sep 29; Bannow, et al
Impact of Fluid Overload on HSCT Outcomes, Biol Blood Marrow Transplant; ePub 2017 Aug 24; Rondón, et al
Survival in Patients with Plasma Cell Myeloma, Leuk Lymphoma; ePub 2017 Jul 21; Santiago, et al