Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

What to Know About a Second-Time Donor Candidate

Biol Blood Marrow Transplant; ePub 2017 Sep 25; Stoncek, et al

Knowing a repeat donor candidate’s first-time experience and stem cell yields could help transplant centers decide if second donations should occur, researchers concluded after conducting a study involving >22,600 individuals. Investigators compared experiences of 1) second-time donors giving marrow (n=118) to those making only 1 marrow donation (n=5,829) and 2) second-time donors giving peripheral blood stem cells (PBSCs; n=602) to first-time PBSC donors (n=16,095). Among the results:

  • There were no substantial differences in maximum skeletal pain, maximum symptoms, or recovery time between second- and first-time donors.
  • The yield of marrow nucleated cells and PBSC CD34+ cells was lower from second donations.
  • Female (PBSC and marrow) and obese donors (PBSC) had higher skeletal pain and/or toxicity with a second donation.
  • PBSC donors who had significant pain/toxicity with the first donation tended to experience the same with second donation—and they took longer to recover.

Citation:

Stoncek D, Shaw B, Logan B, et al. Donor experiences of second marrow or peripheral blood stem cell collection mirror the first, but CD34+ yields are less. [Published online ahead of print September 25, 2017]. Biol Blood Marrow Transplant. doi:10.1016/j.bbmt.2017.09.013.

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