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Rare type of MCL mimics Castleman disease

 

Key clinical point: : In rare cases, Castleman disease-like histologic features can be present in patients mantle cell lymphoma (MCL), and could lead to a misdiagnosis of Castleman disease if careful work-up and flow cytometric analysis are not conducted.

Major finding: Lymph node biopsy revealed histologic features consistent with plasma cell (PC)-type Castleman disease, but cyclin D1 immunostaining and flow cytometric analysis showed features consistent with a diagnosis of MCL.

Data source: A report on three patient cases of MCL with features of PC-type Castleman disease retrieved from surgical pathology consultation files.

Disclosures: The authors reported no conflicts of interest.


 

FROM PATHOLOGY – RESEARCH AND PRACTICE

A rare type of mantle cell lymphoma (MCL) has features that are similar to those of Castleman disease, according to a recent report based on three patient cases.

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