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Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

AGA Clinical Practice Update: Per-Oral Endoscopic Myotomy for Achalasia

Gastroenterology; 2017 Nov; Kahrilas, et al

The latest advice from the American Gastroenterological Association (AGA) on the use of per-oral endoscopic myotomy includes the following recommendations:

  • Practitioners should consider patient-specific parameters when attempting to assess the need for achalasia therapy, including Chicago Classification subtype, the presence of co-existing disorders, whether the patient has early or late disease, and whether there are primary or secondary causes involved.
  • Per-oral endoscopic myotomy is a complex procedure that should be performed by experienced physicians in high volume treatment centers who have had an estimated 20-40 procedures under their belt.
  • Per-oral endoscopic myotomy should be viewed as primary therapy among patients with type III achalasia, assuming the physician has adequate experience.


Kahrilas PJ, Katzka D, Richter JE. Clinical Practice Update: The use of per-oral endoscopic myotomy in achalasia: Expert review and best practice advice from the AGA Institute. Gastroenterology. 2017;153:1205-1211. doi:10.1053/j.gastro.2017.10.001.

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