Obese women may have a higher pregnancy rate during combination oral hormonal contraceptive (COC) use compared to non-obese women, according to a meta-analysis of seven clinical trials with 14,024 obese and non-obese women. An overall hazard ratio of 1.44 suggests a 44% higher pregnancy rate during COC use for obese women after adjusting for age and race.
Citation: Yamazaki M, Dwyer K, Sohban M, et al. Effect of obesity on the effectiveness of hormonal contraceptives: An individual participant data meta-analysis. Contraception. [Published online ahead of print August 3, 2015]. doi: 10.1016/j.contraception.2015.07.016.
1. U.S. Medical Eligibility Criteria for Contraceptive Use, MMWR; 2010(59):1-6.
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