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HF with Recovered EF in African Americans

J Card Fail; ePub 2017 Sep 13; Chang, et al

A small subgroup of African-American heart failure patients with recovered ejection fraction (HFrecEF) and receiving standard of care to improve their ejection fraction (EF) had favorable outcomes, a recent study found. The African-American Heart Failure Trial characterized patients who had significant improvement in their EF during the first 6 months of follow-up. The effects of improvement in EF on all-cause mortality, first, and all hospitalizations were analyzed. Study details include:

  • 59 participants with HFrecEF (improvement in EF from <35% to >40% in 6 months) were compared to 259 with HF and persistently reduced EF (HFrEF), defined as EF ≤40% at 6 months follow-up.
  • Compared to HFrEF, participants with HFrecEF had a non-significant trend towards lower mortality (HR, 0.16), fewer first HF hospitalizations (HR, 0.22), fewer recurrent HF hospitalizations (HR, 0.13), similar first all-cause hospitalizations (HR, 0.67), and fewer recurrent all-cause hospitalizations (HR, 0.41).

Chang K-W, Beri N, Nguyen NH, et al. Heart failure with recovered ejection fraction in African Americans: Results from the African-American Heart Failure Trial. [Published online ahead of print September 13, 2017]. J Card Fail. doi:10.1016/j.cardfail.2017.09.005.

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