Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Bone, Cartilage Cancer Risk Linked with Psoriasis

J Eur Acad Dermatol Venereol; ePub 2017 Sep 28; Jensen, et al

A recent study provides further evidence of an increased cancer of bone and cartilage risk in patients with psoriasis. Researchers identified all patients (n=4,361,869) with a first-time hospital diagnosis of a less common cancer defined as <100 new cases/year/100,000 persons between January 1, 2008, and December 31, 2012. The primary endpoint was the occurrence of a diagnosis of cancer. They found:

  • Of total patients, 58,138 were classified as having psoriasis.
  • After adjusting for age, sex, socioeconomic status, and health care consumption, significantly elevated hazard ratios for cancers of bone and cartilage (HR 4.97 [2.32-10.62]) were discovered in patients with psoriasis on systemic treatment.
Citation:

Jensen P, Egeberg A, Gisalson G, Thyssen, Skov L. Risk of uncommon cancers in patients with psoriasis: A Danish nationwide cohort study. [Published online ahead of print September 28, 2017]. J Eur Acad Dermatol Venereol. doi:10.1111/jdv.14610.

Commentary:

Psoriasis is associated with several comorbidities, including psoriatic arthritis, metabolic syndrome, cardiovascular disease, inflammatory bowel disease, and certain cancers, including lymphoma. The study's investigators aimed to evaluate the risk of less common cancers in patients with psoriasis compared to persons without psoriasis using a nationwide cohort study. They found significantly elevated hazard ratios for cancers of bone and cartilage in patients with psoriasis on systemic treatment. Since approximately 30% of people with psoriasis develop psoriatic arthritis, the correlation between psoriatic arthritis and the risk of skeletal malignancies needs to be determined. —Paul S. Yamauchi, MD, PhD

This Week's Must Reads

Tanning Salon Compliance with Laws Unsatisfactory, JAMA Dermatol; ePub 2017 Oct 25; Williams, et al

Nearly 1 in 4 Skin Biopsies Are Melanocytic Lesions, JAMA Dermatol; ePub 2017 Nov 1; Lott, et al

eConsults Increase Access to Dermatologic Care, J Am Acad Dermatol; ePub 2017 Oct 20; Naka, et al

Obesity Linked with Rosacea Risk in Women, J Am Acad Dermatol; ePub 2017 Oct 21; Li, et al

FDA Approves Stelara for Adolescent Psoriasis, Janssen news release; 2017 Oct 13

Must Reads in Psoriasis

FDA Approves Stelara for Adolescent Psoriasis, Janssen news release; 2017 Oct 13

Pediatric Psoriasis Linked with CV Comorbidities, J Am Acad Dermatol; ePub 2017 Sep 27; Kwa, et al

Treating Transplant Recipients Who Have Psoriasis, J Dermatolog Treat; ePub 2017 Sep 8; Prussick, et al

Secukinumab Treatment in Routine Clinical Care, J Eur Acad Dermatol Venereol; ePub 2017 Sep 27; Körber, et al

Bone, Cartilage Cancer Risk Linked with Psoriasis, J Eur Acad Dermatol Venereol; ePub 2017 Sep 28; Jensen, et al