Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Oral Antibacterial Therapy for Acne Vulgaris

Am J Clin Dermatol; 2017 Aug; Bienenfeld, et al

Tetracyclines, macrolides, and trimethoprim/sulfamethoxazole are effective and safe in the treatment of moderate-to-severe inflammatory acne, according to recent evidenced-based review. A systematic literature review was conducted to identify randomized controlled clinical trials, systematic reviews, and meta-analyses evaluating the efficacy of oral antibiotics for acne. Overall, 41 articles that examined oral antibiotics compared with placebo, another oral therapy, topical therapy, alternate dose, or duration were included in this study. Researchers found:

  • Superior efficacy of one type or class of antibiotic could not be determined. Therefore, the choice of antibiotic is generally based on the side-effect profile.
  • The combination of oral antibiotics with a topical therapy is superior to oral antibiotics alone.
  • Due to increasing resistance to antibiotics, dermatologists should heed consensus guidelines for their appropriate use.

Citation:

Bienenfeld A, Nagler AR, Orlow SJ. Oral antibacterial therapy for acne vulgaris: An evidence-based review. Am J Clin Dermatol. 2017;18(4):469-490. doi:10.1007/s40257-017-0267-z.

This Week's Must Reads

Racial/Ethnic Differences in Childhood Eczema Care, J Am Acad Dermatol; 2017 Dec; Fischer, et al

Eczema Herpeticum Hospitalizations Increase Noted, J Invest Dermatol; ePub 2017 Sep 16; Hsu, Shinkai, et al

Atopic Dermatitis Linked with Hand Eczema, Br J Dermatol; ePub 2017 Nov 24; Ruff, et al

EAPs Aid Patients with Limited Health Literacy , J Cutan Med Surg; ePub 2017 Nov 3; McEvoy, et al

Phenotypical Differences of Adult, Childhood AD, J Allergy Clin Immunol; ePub 2017 Nov 10; Silverberg, et al

Must Reads in Acne

Lasers, Light-Based Treatments Help Manage Acne, J Drugs Dermatol; 2017 Nov; Tong, Brauer

Assessing Facial and Torso Acne Separately, J Cutan Med Surg; ePub 2017 Nov 14; McLellan, et al

Differentiating Pityrosporum Folliculitis and Acne, J Am Acad Dermatol; ePub 2017 Nov 11; Prindaville, et al

Stress, Skin Disease, and Quality of Life, Br J Dermatol; ePub 2017 Oct 27; Dixon, et al

Fractional CO2 Laser Efficient Scar Treatment, Lasers Med Sci; 2017 Dec; Elcin, Yalici-Armagan