Tetracyclines, macrolides, and trimethoprim/sulfamethoxazole are effective and safe in the treatment of moderate-to-severe inflammatory acne, according to recent evidenced-based review. A systematic literature review was conducted to identify randomized controlled clinical trials, systematic reviews, and meta-analyses evaluating the efficacy of oral antibiotics for acne. Overall, 41 articles that examined oral antibiotics compared with placebo, another oral therapy, topical therapy, alternate dose, or duration were included in this study. Researchers found:
- Superior efficacy of one type or class of antibiotic could not be determined. Therefore, the choice of antibiotic is generally based on the side-effect profile.
- The combination of oral antibiotics with a topical therapy is superior to oral antibiotics alone.
- Due to increasing resistance to antibiotics, dermatologists should heed consensus guidelines for their appropriate use.
Bienenfeld A, Nagler AR, Orlow SJ. Oral antibacterial therapy for acne vulgaris: An evidence-based review. Am J Clin Dermatol. 2017;18(4):469-490. doi:10.1007/s40257-017-0267-z.
This Week's Must Reads
Pediatric Psoriasis Linked with CV Comorbidities, J Am Acad Dermatol; ePub 2017 Sep 27; Kwa, et al
Treating Transplant Recipients Who Have Psoriasis, J Dermatolog Treat; ePub 2017 Sep 8; Prussick, et al
Secukinumab Treatment in Routine Clinical Care, J Eur Acad Dermatol Venereol; ePub 2017 Sep 27; Körber, et al
Bone, Cartilage Cancer Risk Linked with Psoriasis, J Eur Acad Dermatol Venereol; ePub 2017 Sep 28; Jensen, et al
Mechanism of Coal Tar Treatment for Psoriasis, J Dermatolog Treat; ePub 2017 Sep 19; Sekhon, et al
Must Reads in Acne
AAD Guidelines for Systemic Antibiotics for Acne, AAD Web site; 2017
Recommendations for Managing Acne Fulminans, J Am Acad Dermatol; 2017 Jul; Greywal, et al
Oral Antibacterial Therapy for Acne Vulgaris, Am J Clin Dermatol; 2017 Aug; Bienenfeld, et al
Endocrine Disorders & Hormonal Therapy for Acne, Curr Opin Pediatr; 2017 Aug; Nguyen, Tollefson
Realistic Expectations for Home Optical Devices, J Cosmet Dermatol; ePub Jul 25; Juhász, et al