Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Lipoprotein(a) and Abdominal Aortic Aneurysm Risk

Atherosclerosis; ePub 2017 Oct 25; Kubota, et al

Elevated lipoprotein(a) [Lp(a)] concentrations are independently associated with an increased risk of abdominal aortic aneurysm (AAA), a recent study found. The Atherosclerosis Risk in Communities study measured plasma Lp(a) in 13,683 participants aged 45 to 64 years in 1987-1989, without a history of AAA surgery. Researchers followed them for incident, clinical AAA events through 2011. They found:

  • There were 505 incident AAA events during 272,914 person-years of follow-up over a median of 22.6 years.
  • Individuals in the highest quintile of plasma Lp(a) had an increased risk of AAA.
  • This positive association was observed in both whites and African Americans.
  • The association reflects a threshold of AAA risk at high Lp(a) concentrations, rather than a steady monotonic association.
Citation:

Kubota Y, Folsom AR, Ballantyne CM, Tang W. Lipoprotein(a) and abdominal aortic aneurysm risk: The Atherosclerosis Risk on Communities study. [Published online ahead of print October 25, 2017]. Atherosclerosis. doi:10.1016/j.atherosclerosis.2017.10.017.

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