Children with familial hypercholesterolemia (FH) had higher atherogenic ApoB-containing lipoproteins and lipid fractions, as well as alterations in HDL sub fractions that suggest impaired reverse cholesterol transport, when compared to healthy children, a recent study found. The cross-sectional study measured plasma metabolites in children with FH (n=47) and in healthy children (n=57) using a high-throughput nuclear magnetic resonance (NMR) spectroscopy platform, and compared the differences between FH and healthy children. Researchers found:
- Both statin treated (n=17) and non-statin treated FH children (n=30) had higher levels of atherogenic ApoB-containing lipoproteins and lipids, and lipid fractions in lipoprotein subclasses, compared to healthy children.
- Children with FH displayed alterations in HDL particle concentration and lipid content vs healthy children.
- Global alterations roughly displayed the opposite effect of statin treatment in adults.
- NMR-based lipidomics may improve risk classification and guide treatment intensity.
Christensen JJ, Ulven SM, Retterstøl K, et al. Comprehensive lipid and metabolic profiling of children with and without familial hypercholesterolemia: A cross-sectional study. [Published online ahead of print September 20, 2017]. doi:10.1016/j.atherosclerosis.2017.09.021.
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