Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

LDL Pattern & Mortality After Myocardial Infarction

J Clin Lipidol; ePub 2017 Oct 3; Pokharel, et al

Compared with low-density lipoprotein (LDL) pattern A, pattern B was significantly associated with reduced all-cause and non-cardiovascular (CV) mortality with a trend for lower CV mortality after MI, a recent study found. This association was independent of LDL-C and triglycerides, according to results from the TRIUMPH Study that examined the association of LDL pattern after MI and death among 2,476 patients hospitalized for MI. Researchers found:

  • Patterns A, A/B, and B were present in 39%, 28%, and 33% of patients, respectively, with incident rates (per 1,000 patient-years) of 50, 34, and 24 for all-cause and 24, 19, and 10 for CV mortality.
  • Pattern B was independently associated with lower risk for all-cause death than A.
  • Results were similar for non-CV death with similar trend for CV-death.

Pokharel Y, Tang Y, Bhardwaj B, et al. Association of low density lipoprotein pattern with mortality after myocardial infarction: Insights from the TRIUPMH Study. [Published online ahead of print October 3, 2017]. J Clin Lipidol. doi:10.1016/j.jacl.2017.09.002.

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