Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Increased Risk of HF and AF in Patients With FH

Atherosclerosis; 2017 Nov; Hovland, Mundal, et al

Patients with familial hypercholesterolemia (FH) have twice the risk of hospitalization for heart failure (HF) or atrial fibrillation (AF) compared to those without FH, a recent study found. The study included 4,273 genotyped FH patients (51.7% women) with a total observational period of 18,300 patient years and estimated incidence rates of hospitalization for HF and AF. Researchers found:

  • Overall, the expected number of FH patients with HF was 27.7 and the observed number of cases was 54.
  • The highest excess risk was observed in those aged 25-49 years.
  • The total expected number of FH patients with AF was 39.4 while the observed number of cases was 77.
  • Among FH patients with an incident HF event, ~90% had a previous diagnosis of coronary artery disease (CAD), and ~40% had had a myocardial infarction.

Hovland A, Mundal LJ, Igland J, et al. Increased risk of heart failure and atrial fibrillation in heterozygous familial hypercholesterolemia. Atherosclerosis. 2017;266:69-73. doi:10.1016/j.atherosclerosis.2017.09.027.

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