Patients with familial hypercholesterolemia (FH) have twice the risk of hospitalization for heart failure (HF) or atrial fibrillation (AF) compared to those without FH, a recent study found. The study included 4,273 genotyped FH patients (51.7% women) with a total observational period of 18,300 patient years and estimated incidence rates of hospitalization for HF and AF. Researchers found:
- Overall, the expected number of FH patients with HF was 27.7 and the observed number of cases was 54.
- The highest excess risk was observed in those aged 25-49 years.
- The total expected number of FH patients with AF was 39.4 while the observed number of cases was 77.
- Among FH patients with an incident HF event, ~90% had a previous diagnosis of coronary artery disease (CAD), and ~40% had had a myocardial infarction.
Hovland A, Mundal LJ, Igland J, et al. Increased risk of heart failure and atrial fibrillation in heterozygous familial hypercholesterolemia. Atherosclerosis. 2017;266:69-73. doi:10.1016/j.atherosclerosis.2017.09.027.
This Week's Must Reads
AHA/ACC Issues New Hypertension Guidelines , Hypertension; ePub 2017 Nov 13; Whelton, et al
Guidelines Focus on Ventricular Arrhythmias & SCD, J Am Coll Cardiol; ePub 2017 Oct 30; Al-Khatib, et al
CAC Scores in T2D & Metabolic Syndrome Patients, JAMA Cardiol; ePub 2017 Nov 8; Malik, et al
Consistency of BP Control & All-Cause Mortality, J Am Heart Assoc; ePub 2017 Nov 3; Doumas, et al
Reproductive Life Span as Risk for CVD, J Am Heart Assoc; ePub 2017 Nov 3; Ley, et al
Must Reads in Hypercholesterolemia
Hypercholesterolemia & Sitosterolemia Linked, J Clin Lipidol; ePub 2017 Oct 27; Brinton, et al
Lipoprotein(a) and Abdominal Aortic Aneurysm Risk, Atherosclerosis; ePub 2017 Oct 25; Kubota, et al
Rate of LCL-C Control Among Uninsured Adults, J Am Heart Assoc; ePub 2017 Nov 2; Egan, et al
Successful Prescribing of PCSK9 Inhibitor Therapy , Circulation; ePub 2017 Oct 30; Hess, et al
Does Bariatric Surgery Improve Lipoprotein Profile?, J Clin Lipidol; ePub 2017 Oct 25; Kjellmo, et al