Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Hypercholesterolemia & Sitosterolemia Linked

J Clin Lipidol; ePub 2017 Oct 27; Brinton, et al

Approximately 4% of individuals with low-density lipoprotein cholesterol (LDL-C) concentrations ≥190 mg/dL have plasma β-sitosterol concentrations above the 99th percentile and ~0.3% have concentrations consistent with sitosterolemia, a recent study found. The study included 207,926 participants and examined the relationship between hypercholesterolemia and sitosterolemia. Plasma concentrations were measured by gas chromatography/mass spectrometry and LDL-C by direct assay. Researchers found:

  • 4.3% of participants tested had LDL-C ≥190 mg/dL.
  • Sitosterolemia occurs relatively commonly in patients with LDL-C ≥190 mg/dL.
  • Sitosterolemia responds well to diet and statin therapy.
  • The diagnosis of sitosterolemia should be considered in patients with ≥190 mg/dL.

Brinton EA, Hopkins PN, Hegele RA, et al. The association between hypercholesterolemia and sitosterolemia, and report of a sitosterolemia kindred. [Published online ahead of print October 27, 2017]. J Clin Lipidol. doi:10.1016/j.jacl.2017.10.013.

This Week's Must Reads

AHA/ACC Issues New Hypertension Guidelines , Hypertension; ePub 2017 Nov 13; Whelton, et al

Guidelines Focus on Ventricular Arrhythmias & SCD, J Am Coll Cardiol; ePub 2017 Oct 30; Al-Khatib, et al

CAC Scores in T2D & Metabolic Syndrome Patients, JAMA Cardiol; ePub 2017 Nov 8; Malik, et al

Consistency of BP Control & All-Cause Mortality, J Am Heart Assoc; ePub 2017 Nov 3; Doumas, et al

Reproductive Life Span as Risk for CVD, J Am Heart Assoc; ePub 2017 Nov 3; Ley, et al

Must Reads in Hypercholesterolemia

Hypercholesterolemia & Sitosterolemia Linked, J Clin Lipidol; ePub 2017 Oct 27; Brinton, et al

Lipoprotein(a) and Abdominal Aortic Aneurysm Risk, Atherosclerosis; ePub 2017 Oct 25; Kubota, et al

Rate of LCL-C Control Among Uninsured Adults, J Am Heart Assoc; ePub 2017 Nov 2; Egan, et al

Successful Prescribing of PCSK9 Inhibitor Therapy , Circulation; ePub 2017 Oct 30; Hess, et al

Does Bariatric Surgery Improve Lipoprotein Profile?, J Clin Lipidol; ePub 2017 Oct 25; Kjellmo, et al