Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Psoriasis, PsA Associated with Liver Disease

J Invest Dermatol; ePub 2017 Nov 2; Ogdie, et al

More so than rheumatoid arthritis (RA), psoriasis (PsO) and psoriatic arthritis (PsA) are associated with liver disease, particularly non-alcoholic fatty liver disease (NAFLD) and cirrhosis, and this was true even among patients without systemic therapy (ST) exposure, according to a recent study. Researchers performed a cohort study among patients with PsO, PsA, or RA and matched controls in The Health Improvement Network from 1994-2014. Outcomes of interest were any liver disease, NAFLD, and cirrhosis (any etiology). They found:

  • Among patients with psoriasis (n=197,130), PsA (n=12,308), RA (n=54,251), and matched controls (n=1,279,754), the adjusted hazard ratios for any liver disease were elevated among patients with PsO, PsA, and RA without a ST but not elevated in RA patients prescribed a ST.
  • Incident NAFLD was highest in patients with PsO prescribed a ST and PsA with a ST.
  • Risk of cirrhosis was highest among patients with PsO with a ST and PsA without a ST.
  • Additionally, the prevalence of liver disease and cirrhosis increased in a stepwise fashion with increasing body surface area affected by PsO.


Ogdie A, Grewal SK, Noe MH, et al. Risk of incident liver disease in patients with psoriasis, psoriatic arthritis, and rheumatoid arthritis: A population-based study. [Published online ahead of print November 2, 2017]. J Invest Dermatol. doi:10.1016/j.jid.2017.10.024.

This Week's Must Reads

SK: Strong Risk Predictor of Developing AV Block, Clin Cardiol; ePub 2017 Nov 23; Roshdy, et al

TADA Compares Favorably as Diagnostic Tool, Dermatol Pract Concept; 2017 Apr; Rogers, et al

Diagnosis of SK Is Challenging to the Naked Eye , J Dermatol; 2017 May; Minagawa

Genetic Alterations in Seborrheic Keratoses, Oncotarget; 2017 May; Heidenreich, et al

Rare Cutaneous Benign Tumor (RASD) Can Mimic SK , Dermatol Pract Concept; 2017 Jul; Ribiero, Leocadia, et al

Must Reads in Psoriasis

Psoriasis and Diabetes Risk Examined in Cohort, J Am Acad Dermatol; ePub 2017 Nov 8; Wan, et al

Psoriasis, PsA Associated with Liver Disease, J Invest Dermatol; ePub 2017 Nov 2; Ogdie, et al

FDA Approves Stelara for Adolescent Psoriasis, Janssen news release; 2017 Oct 13

FDA Approves Tremfya for Plaque Psoriasis, Janssen Biotech Inc. news release; 2017 Jul 13

Dietary Behaviors of Patients with Psoriasis, Dermatol Ther; ePub 2017 May 19; Afifi, Danesh, et al