Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Program Aids Adherence to Depression Treatment

JAMA Psychiatry; ePub 2017 Sep 27; Sirey, et al

The Treatment Initiation and Participation (TIP) Program is an effective intervention to improve early adherence to antidepressant medication, a recent study found, and improved adherence can promote improvement in depression. In order test the effectiveness of a psychosocial intervention to improve early adherence among older patients whose primary care physician newly initiated an antidepressant for depression, researchers offered the TIP in a 2-site randomized clinical effectiveness study between January 2011 and December 2014 at primary care practices in 2 major US cities. All participants were aged ≥55 years, had received newly initiated depression treatment by their primary care physician, and were recruited within 10 days of their prescription. In total, 167 women (72.3%) and 64 men (27.7%) without significant cognitive impairment were randomly assigned to the TIP intervention (n=115) or treatment as usual (n=116). Researchers found:

  • Participants in the TIP group were 5 times more likely to be adherent at 6 weeks and 3 times more likely to be adherent at both 6 and 12 weeks.
  • Participants in the TIP group showed a significant earlier reduction (24.9%) in depressive symptoms.
Citation:

Sirey JA, Banerjee S, Marino P, et al. Adherence to depression treatment in primary care. A randomized clinical trial. [Published online ahead of print September 27, 2017]. JAMA Psychiatry. doi:10.1001/jamapsychiatry.2017.3047.

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