Both women and men were at increased risk of papillary thyroid cancer (PTC) depending on their thyroid-stimulating hormone (TSH) level, according to a nested case–control study involving nearly 1,500 individuals. TSH levels in men and women produced different outcomes. Participants either had PTC (n=741) or served as matched controls (n=741). Investigators measured TSH, total T3, total T4, and free T4. Among the results:
- A median of ~1,450 days passed between blood draw and PTC diagnosis.
- Women with normal or low TSH levels were nearly 4 times more likely than those with TSH levels in the middle tertile within normal range to develop PTC
- Men with high TSH levels were nearly twice as likely to develop PTC.
- Overall, PTC risk decreased with increasing TSH levels within the normal range.
The authors noted that the results could impact clinical decisions in patients with abnormal thyroid functions, as well as those with thyroidectomy.
Huang H, Rusiecki J, Zhao N, et al. Thyroid-stimulating hormone, thyroid hormones, and risk of papillary thyroid cancer: A nested case–control study. Cancer Epidemiol Biomarkers Prev. 2017;26(8):1209-1218. doi:10.1158/1055-9965.EPI-16-0845.
This Week's Must Reads
Cochrane on Clinician-Focused Weight Loss Tactics, Cochrane; 2017 Nov 30; Flodgren, et al
Cochrane on Delaying Diabetes in People with IGT, Cochrane; 2017 Dec 5; Hemmingsen, et al
Consider Using This Risk Tool to Predict T2D Risk, Diabetes Care; ePub 2017 Dec 1; Bergmark, Bhatt, et al
Dysglycemia Cause in Overweight Adults, Teens, Diabetes Care; ePub 2017 Nov 28; Chen, et al
FDA Approves Semaglutide for Type 2 Diabetes, Novo Nordisk news release; 2017 Dec 5
Must Reads in Pituitary, Thyroid & Adrenal Disorders
Medically Treated Primary Aldosteronism Outcomes, Lancet Diabetes Endocrinol; ePub 2017 Nov 9; Hundemer, et al
Thyroid Function in Older Adults Evaluated, Thyroid; ePub 2017 Oct 13; Mammen, McGready, et al
Endocrinopathies with Cancer Immunotherapy Use, Clin Endocrinol (Oxf); ePub 2017 Oct 9; Villa, et al
TSH Levels and Papillary Thyroid Ca in Men, Women, Cancer Epidemiol Biomarkers Prev; 2017 Aug; Huang, et al
Use This to Confirm Indeterminate Adrenal Lesions, Clin Endocrinol (Oxf); ePub 2017 Sep 5; Delivanis, et al