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Tracking This Over Time Predictive in Diabetes

Diabetes Care; ePub 2017 Oct 27; Jun, et al

Monitoring albuminuria change over time appears to have predictive value in people with type 2 diabetes, researchers concluded after conducting an analysis involving nearly 8,800 individuals from the ADVANCE-ON study. Investigators calculated urine albumin-to-creatinine ratio (UACR) change over 2 years and categorized patients as follows: decrease of ≥30%, minor change, or increase of ≥30%. They looked at the impact on a composite of major macrovascular events, renal events, and all-cause mortality. Among the results:

  • Over a median follow-up of ~7.5 years, nearly 2,200 incidences of the composite outcome were seen.
  • The composite outcome was 26% higher in patients with a UACR increase than it was in those with a minor change.
  • After allowing for regression to the mean, the composite outcome was 16% lower in those with a UACR decrease.
  • Impact of the UACR increase remained unchanged after allowing for regression to the mean.
Citation:

Jun M, Ohkuma T, Zoungas S, et al. Changes in albuminuria and the risk of major clinical outcomes in diabetes: Results from ADVANCE-ON. [Published online ahead of print October 27, 2017]. Diabetes Care. doi:10.2337/dc17-1467.

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